India's No: 1 Ranked Institute, IIT Madras & Danish University Study reveals Genetic 'Switches' that can transform Disease Research - Thailand PR News - [Banking](https://thailandbusinessnews.net/category/banking/) - [Companies](https://thailandbusinessnews.net/category/companies/) - [Economy](https://thailandbusinessnews.net/category/economy/) - [Press Releases](https://thailandbusinessnews.net/category/press-release/) - [PR Newswire](https://thailandbusinessnews.net/pr-newswire-updates/) - [Tech](https://thailandbusinessnews.net/category/tech/) - [Tourism](https://thailandbusinessnews.net/category/tourism/) - [Press Release](https://thailandbusinessnews.net/category/press-release/) # India's No: 1 Ranked Institute, IIT Madras & Danish University Study reveals Genetic 'Switches' that can transform Disease Research ##### Up next ![C-Ray Therapeutics (Shanghai) Co., Ltd. Presents Breakthrough Clinical Data of Novel Targeted Alpha Therapy 225Ac-PSMA-CY313 at EANM 2025](https://i0.wp.com/r2.thailandbusinessnews.net/2025/10/20251008113537_466_2.jpg?resize=200%2C110&ssl=1 "C-Ray Therapeutics (Shanghai) Co., Ltd. Presents Breakthrough Clinical Data of Novel Targeted Alpha Therapy 225Ac-PSMA-CY313 at EANM 2025") [](https://thailandbusinessnews.net/press-release/c-ray-therapeutics-shanghai-co-ltd-presents-breakthrough-clinical-data-of-novel-targeted-alpha-therapy-225ac-psma-cy313-at-eanm-2025/) ###### [C-Ray Therapeutics (Shanghai) Co., Ltd. Presents Breakthrough Clinical Data of Novel Targeted Alpha Therapy 225Ac-PSMA-CY313 at EANM 2025](https://thailandbusinessnews.net/press-release/c-ray-therapeutics-shanghai-co-ltd-presents-breakthrough-clinical-data-of-novel-targeted-alpha-therapy-225ac-psma-cy313-at-eanm-2025/) Published on 08 October 2025 ##### Author ##### [ CISION PRNewswire ](https://thailandbusinessnews.net/author/cision/) ##### Tags - [PRNewswire](https://thailandbusinessnews.net/tag/prnewswire/) CHENNAI, India, Oct. 8, 2025 /PRNewswire/ — India’s No:1 Ranked Institute, the [Indian Institute of Technology Madras](https://www.iitm.ac.in/), and Danish researchers have shown how interactions between genetic variants can act like ‘switches’ to unlock hidden cellular pathways. [![IIT Madras Campus](https://mma.prnasia.com/media2/2791473/IIT_MADRAS_Campus.jpg?p=medium600 "IIT Madras Campus")](https://mma.prnasia.com/media2/2791473/IIT_MADRAS_Campus.jpg?p=medium600) IIT Madras Campus The findings of this research, undertaken jointly with the Technical University of Denmark, were published in a research paper in the prestigious, internationally-renowned Nature Communications journal (DOI: 10.1038/s41467-025-63306-4), an open-access journal also published by Springer Nature. In this study, the researchers, using systems-level multi-omic approaches, showed how genetic variants in yeast work together to activate previously dormant metabolic pathways. By revealing how these gene–gene interactions dynamically rewire metabolism, the study provides a powerful framework for decoding how multiple genes combine to modify and improve complex phenotypes. The research was led by Mr. Srijith Sasikumar, a PhD student, and Prof. Himanshu Sinha, from the Department of Biotechnology, IIT Madras, in collaboration with Dr. Shannara Taylor Parkins and Dr. Suresh Sudarsan from the Technical University of Denmark. Elaborating on the importance of this research, Prof. Himanshu Sinha, Department of Biotechnology, IIT Madras, said, "The implications of this discovery extend well beyond yeast. Many complex human diseases—including cancer, diabetes, and neurodegenerative disorders—arise from the interplay of multiple genes rather than single mutations. The IIT Madras study provides a mechanistic framework for studying these interactions systematically." Further, Mr. Srijith Sasikumar, PhD student, Department of Biotechnology, IIT Madras, added, "It is like flipping two switches at once suddenly, a hidden backup circuit turns on, and the whole system behaves differently. This shows us that genes don’t just act alone, but their interaction can create new outcomes that we would never see otherwise." The practical applications of this research include the development of biomarkers and the identification of drug targets that capture the combined effects of genetic variants, enabling more accurate disease diagnosis, prognosis, and the design of personalized treatment strategies tailored to an individual’s unique genetic background. Beyond medicine, the framework may also find applications in industrial biotechnology, where rewiring metabolic pathways in microorganisms can be used to optimise biofuel production, and in enhancing agricultural research, to improve crop and animal yields. Together, these applications highlight how a discovery in a simple organism like yeast can translate into far-reaching benefits for human health, industry, and society. [Source link ](https://www.prnasia.com/story/archive/4793120_AE93120_0?rand=89749) ``` This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network ``` ##### You May Also Like [](https://thailandbusinessnews.net/press-release/ab-token-is-now-live-on-bingx-deposit-trade-to-share-6-2-million-ab-rewards/) ## AB Token is Now Live on BingX – Deposit & Trade to Share 6.2 Million AB Rewards SINGAPORE, March 6, 2025 /PRNewswire/ — AB DAO has officially announced that… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - March 6, 2025 [](https://thailandbusinessnews.net/press-release/vt-academy-unveils-free-comprehensive-trading-education-to-cater-to-traders-of-all-levels/) ![VT Academy Unveils Free, Comprehensive Trading Education to Cater to Traders of all Levels](https://i0.wp.com/r2.thailandbusinessnews.net/2025/11/VT_Academy_Unveils_Free_Comprehensive_Trading_Education_Cater_Traders_Levels.jpg?resize=260%2C140&ssl=1 "VT Academy Unveils Free, Comprehensive Trading Education to Cater to Traders of all Levels") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## VT Academy Unveils Free, Comprehensive Trading Education to Cater to Traders of all Levels SYDNEY, Nov. 11, 2025 /PRNewswire/ — VT Academy, the educational platform from… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - November 11, 2025 [](https://thailandbusinessnews.net/press-release/otis-elevator-integrates-with-a-delivery-robot-at-new-zealand-hotel/) ![Otis Elevator Integrates with a Delivery Robot at New Zealand Hotel](https://i0.wp.com/r2.thailandbusinessnews.net/2025/04/1745975912_Photo_1.jpg?resize=260%2C140&ssl=1 "Otis Elevator Integrates with a Delivery Robot at New Zealand Hotel") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## Otis Elevator Integrates with a Delivery Robot at New Zealand Hotel A first for Otis in New Zealand, Otis is integrating service robots… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - April 30, 2025 ##### Most Read - [![Priority Pass to accelerate travel innovation, backed by the Collinson Group's £500 million growth programme](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/priority-pass-to-accelerate-travel-innovation-backed-by-the-collinson-groups-500-million-growth-programme-2/ "Priority Pass to accelerate travel innovation, backed by the Collinson Group's £500 million growth programme") [Priority Pass to accelerate travel innovation, backed by the Collinson Group's £500 million growth programme](https://thailandbusinessnews.net/press-release/priority-pass-to-accelerate-travel-innovation-backed-by-the-collinson-groups-500-million-growth-programme-2/ "Priority Pass to accelerate travel innovation, backed by the Collinson Group's £500 million growth programme") - [![Modern Meadow and Bellroy Partner on Carry Products Made of Next-Generation Material](https://i0.wp.com/r2.thailandbusinessnews.net/2025/04/MODERN_MEADOW_LOGO_BLACK_PNG_Logo.jpg?fit=597%2C138&ssl=1&resize=40%2C40)](https://thailandbusinessnews.net/press-release/modern-meadow-and-bellroy-partner-on-carry-products-made-of-next-generation-material/ "Modern Meadow and Bellroy Partner on Carry Products Made of Next-Generation Material") [Modern Meadow and Bellroy Partner on Carry Products Made of Next-Generation Material](https://thailandbusinessnews.net/press-release/modern-meadow-and-bellroy-partner-on-carry-products-made-of-next-generation-material/ "Modern Meadow and Bellroy Partner on Carry Products Made of Next-Generation Material") - [![IMG Completes Acquisition of World Nomads, Expanding Global Travel Insurance Distribution](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/img-completes-acquisition-of-world-nomads-expanding-global-travel-insurance-distribution/ "IMG Completes Acquisition of World Nomads, Expanding Global Travel Insurance Distribution") [IMG Completes Acquisition of World Nomads, Expanding Global Travel Insurance Distribution](https://thailandbusinessnews.net/press-release/img-completes-acquisition-of-world-nomads-expanding-global-travel-insurance-distribution/ "IMG Completes Acquisition of World Nomads, Expanding Global Travel Insurance Distribution") - [![DORCO Wins 2026 Red Dot Award for Renewed Corporate Identity](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/dorco-wins-2026-red-dot-award-for-renewed-corporate-identity/ "DORCO Wins 2026 Red Dot Award for Renewed Corporate Identity") [DORCO Wins 2026 Red Dot Award for Renewed Corporate Identity](https://thailandbusinessnews.net/press-release/dorco-wins-2026-red-dot-award-for-renewed-corporate-identity/ "DORCO Wins 2026 Red Dot Award for Renewed Corporate Identity") - [![Tamarind Health launches Rare Cancer Centre to make specialist expertise easier to access](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/tamarind-health-launches-rare-cancer-centre-to-make-specialist-expertise-easier-to-access/ "Tamarind Health launches Rare Cancer Centre to make specialist expertise easier to access") [Tamarind Health launches Rare Cancer Centre to make specialist expertise easier to access](https://thailandbusinessnews.net/press-release/tamarind-health-launches-rare-cancer-centre-to-make-specialist-expertise-easier-to-access/ "Tamarind Health launches Rare Cancer Centre to make specialist expertise easier to access") - [![MemoMind One Rolls Out New Features and Prepares for a New Stage of Developer Access](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/memomind-one-rolls-out-new-features-and-prepares-for-a-new-stage-of-developer-access/ "MemoMind One Rolls Out New Features and Prepares for a New Stage of Developer Access") [MemoMind One Rolls Out New Features and Prepares for a New Stage of Developer Access](https://thailandbusinessnews.net/press-release/memomind-one-rolls-out-new-features-and-prepares-for-a-new-stage-of-developer-access/ "MemoMind One Rolls Out New Features and Prepares for a New Stage of Developer Access") ##### Subscribe via Email Enter your email address to subscribe and receive notifications of new posts by email. Email Address Subscribe [](https://thailandbusinessnews.net/press-release/nuix-takes-to-sibos-2026-to-help-financial-institutions-turn-complex-data-into-financial-crime-intelligence/) ## Nuix Takes to Sibos 2026 to help Financial Institutions Turn Complex Data into Financial Crime Intelligence MIAMI, Oct. 2, 2026 /PRNewswire/ — Nuix, a global leader in investigative… [](https://thailandbusinessnews.net/press-release/hyundai-motor-unveils-the-all-new-tucson-its-boldest-suv/) ![Hyundai Motor Unveils the All-New TUCSON, Its Boldest SUV](https://i0.wp.com/mmx.prnasia.com/media/MS2001342/Image-Hyundai-Motor-Unveils-the-All-New-TUCSON-Its-Boldest-SUV_1.jpg?resize=260%2C140&ssl=1 "Hyundai Motor Unveils the All-New TUCSON, Its Boldest SUV") ## Hyundai Motor Unveils the All-New TUCSON, Its Boldest SUV The all-new TUCSON embodies the "Boldest SUV" vision through its "Art of… [](https://thailandbusinessnews.net/press-release/singcore-unveils-s1-pro-an-all-in-one-ai-karaoke-system-launching-on-kickstarter-in-october-2026/) ![Singcore Unveils S1 Pro: an All-in-One AI Karaoke System Launching on Kickstarter in October 2026](https://i0.wp.com/mmx.prnasia.com/media/MS2001284/20261001192407EDT_image_1.jpg?resize=260%2C140&ssl=1 "Singcore Unveils S1 Pro: an All-in-One AI Karaoke System Launching on Kickstarter in October 2026") ## Singcore Unveils S1 Pro: an All-in-One AI Karaoke System Launching on Kickstarter in October 2026 RANCHO CUCAMONGA, Calif., Oct. 2, 2026 /PRNewswire/ — Singcore, an AI singing… [](https://thailandbusinessnews.net/press-release/invt-at-dcw-asia-2026-power-and-cooling-for-higher-density-data-centers/) ![INVT at DCW Asia 2026: Power and Cooling for Higher-Density Data Centers](https://i0.wp.com/mmx.prnasia.com/media/MS1999558/20260930043116EDT_image_1.jpg?resize=260%2C140&ssl=1 "INVT at DCW Asia 2026: Power and Cooling for Higher-Density Data Centers") ## INVT at DCW Asia 2026: Power and Cooling for Higher-Density Data Centers SINGAPORE, Oct. 2, 2026 /PRNewswire/ — INVT showcased integrated power and liquid…