HanchorBio Secures US Patent for Innovative SIRPα/CD47 Fusion Protein HCB101 - Thailand PR News - [Banking](https://thailandbusinessnews.net/category/banking/) - [Companies](https://thailandbusinessnews.net/category/companies/) - [Economy](https://thailandbusinessnews.net/category/economy/) - [Press Releases](https://thailandbusinessnews.net/category/press-release/) - [PR Newswire](https://thailandbusinessnews.net/pr-newswire-updates/) - [Tech](https://thailandbusinessnews.net/category/tech/) - [Tourism](https://thailandbusinessnews.net/category/tourism/) - [Press Release](https://thailandbusinessnews.net/category/press-release/) # HanchorBio Secures US Patent for Innovative SIRPα/CD47 Fusion Protein HCB101 ##### Up next ![Iridium Awarded U.S. Department of Transportation Contract for Complementary Positioning, Navigation, and Timing Services Deployment and Testing](https://i0.wp.com/r2.thailandbusinessnews.net/2025/10/Iridium_Satellite_Network.jpg?resize=200%2C110&ssl=1 "Iridium Awarded U.S. Department of Transportation Contract for Complementary Positioning, Navigation, and Timing Services Deployment and Testing") [](https://thailandbusinessnews.net/press-release/iridium-awarded-u-s-department-of-transportation-contract-for-complementary-positioning-navigation-and-timing-services-deployment-and-testing/) ###### [Iridium Awarded U.S. Department of Transportation Contract for Complementary Positioning, Navigation, and Timing Services Deployment and Testing](https://thailandbusinessnews.net/press-release/iridium-awarded-u-s-department-of-transportation-contract-for-complementary-positioning-navigation-and-timing-services-deployment-and-testing/) Published on 21 October 2025 ##### Author ##### [ CISION PRNewswire ](https://thailandbusinessnews.net/author/cision/) ##### Tags - [PRNewswire](https://thailandbusinessnews.net/tag/prnewswire/) TAIPEI and SHANGHAI and SAN FRANCISCO, Oct. 21, 2025 /PRNewswire/ — HanchorBio today announced that its proprietary HCB101, a SIRPα/CD47 fusion protein candidate, has been officially granted a US patent (Patent No. 12,447,195) by the United States Patent and Trademark Office (USPTO). Titled "ENGINEERED SIRPα VARIANTS AND METHODS OF USE THEREOF", the patent represents major international recognition for the company’s innovative technology for immuno-oncology. Mechanism of Action and Novelty of HCB101: An Innovative Fusion Protein Design Developed using HanchorBio’s proprietary FBDB™ (Fc-Based Designed Biologics) platform, HCB101 is an engineered SIRPα/CD47 fusion protein designed to precisely modulate the immune system’s recognition and phagocytic functions, effectively overcoming the challenge of tumor immune evasion and enhancing the clearance of cancer cells. The molecule employs an engineered variant strategy, featuring novel amino acid substitutions at previously unclaimed and undisclosed SIRPα sites.These innovative structural mutations significantly enhance the binding affinity and functional potency of HCB101 toward CD47 expressed on tumor cells, thereby reactivating macrophage-mediated cancer cell killing while minimizing the hematologic toxicities commonly associated with traditional CD47 monoclonal antibody therapies. The USPTO recognized HCB101’s original mutation design and unprecedented potency as clear evidence of novelty and inventive step, distinguishing it from prior technologies and enabling the molecule to successfully pass the rigorous US patent examination process. In addition to robust intellectual property protection, the patent also strengthens HanchorBio’s position for licensing negotiations and strategic collaborations, further enhancing its global partnership and value creation potential. Dr. Scott Liu, Chairman of HanchorBio, commented: "The US patent grant for HCB101 is a testament to HanchorBio’s robust R&D capabilities in immunotherapy, while also illustrating the heights of innovation that Taiwan’s biotech industry is capable of reaching. Backed by a solid IP position, we are committed to further expanding global collaboration." Why the United States: A Strategic and Symbolic First Step HanchorBio strategically selected the United States as the first jurisdiction for patent filing and issuance, recognizing it as the world’s most influential and standard-bearing market for biopharmaceutical innovation and licensing. US patent approval often serves as a benchmark for patent examiners in other countries, amplifying both credibility and momentum for subsequent filings. For the filing, HanchorBio worked with Fish & Richardson, one of the largest and most respected intellectual property law firms in the US. The successful approval of HCB101’s US patent demonstrates the molecule’s technical originality and therapeutic advancement, paving the way for accelerated future examinations in Europe and multiple Asian territories. Dr. Wenwu Zhai, Chief Scientific Officer of HanchorBio, remarked:"We prioritized the US market as the foundation of our IP strategy, as its market scale and influence align closely with our long-term growth objectives. Building on this milestone, we will further build a comprehensive global IP protection network." Global Patent Strategy: Strengthening Licensing and Partnerships Following this US patent grant, HanchorBio will advance patent filings across Europe, Taiwan, and other Asian countries as part of its broader global IP roadmap.This strategy aims to consolidate the company’s leadership in immuno-oncology and fusion protein drug development, while significantly enhancing its negotiating power for international licensing and co-development opportunities. The HCB101 patent represents not only a technological milestone but also a pivotal step in HanchorBio’s journey toward global market expansion. About HanchorBio Based in Taipei, Shanghai, and the San Francisco Bay Area, HanchorBio (7827.TWO), a global biotechnology company specializing in immuno-oncology, is led by an experienced team of pharmaceutical industry veterans with a proven track record of success in biologics discovery and global development, aiming to rewrite cancer therapies. Committed to reactivating the immune system to fight diseases, the proprietary Fc-based designer biologics (FBDB™) platform enables the development of unique biologics with diverse multi-targeting modalities, unleashing both innate and adaptive immunity to overcome the current challenges of anti-PD1/L1 therapies. The FBDB™ platform has successfully delivered proof-of-concept data in several in vivo tumor animal models. By making breakthroughs in multi-functional innovative molecular configurations in R&D and improving the manufacturing process in CMC, HanchorBio develops transformative medicines to address unmet medical needs. For more information, please visit: [https://www.HanchorBio.com](https://www.hanchorbio.com/) [Source link ](https://www.prnasia.com/story/archive/4800672_HK00672_0?rand=89749) ``` This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network ``` ##### You May Also Like [](https://thailandbusinessnews.net/press-release/mayor-of-plano-u-s-visits-sk-signet-headquarters-to-strengthen-north-american-ev-charging-infrastructure-partnership/) ![Mayor of Plano, U.S., Visits SK Signet Headquarters to Strengthen North American EV Charging Infrastructure Partnership](https://i0.wp.com/mma.prnasia.com/media2/2949562/Photo1__SK_Signet_CEO_Hyung_Ki_Cho_executives_pose_Plano_Mayor.jpg?resize=260%2C140&ssl=1 "Mayor of Plano, U.S., Visits SK Signet Headquarters to Strengthen North American EV Charging Infrastructure Partnership") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## Mayor of Plano, U.S., Visits SK Signet Headquarters to Strengthen North American EV Charging Infrastructure Partnership SEOUL, South Korea, April 6, 2026 /PRNewswire/ — SK Signet (KONEX: 260870),… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - April 6, 2026 [](https://thailandbusinessnews.net/press-release/innovation-meets-inclusion-edheroes-global-forum-2025-explore-the-human-centered-future-of-education-technology/) ![Innovation Meets Inclusion: EdHeroes Global Forum 2025 Explore the Human-Centered Future of Education Technology](https://i0.wp.com/r2.thailandbusinessnews.net/2025/07/edheroes_global_forum_2025.jpg?resize=260%2C140&ssl=1 "Innovation Meets Inclusion: EdHeroes Global Forum 2025 Explore the Human-Centered Future of Education Technology") - [Press Release](https://thailandbusinessnews.net/category/press-release/) - [Tech](https://thailandbusinessnews.net/category/tech/) ## Innovation Meets Inclusion: EdHeroes Global Forum 2025 Explore the Human-Centered Future of Education Technology TRIESEN, Liechtenstein, July 22, 2025 /PRNewswire/ — As innovation accelerates and technology redefines… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - July 22, 2025 [](https://thailandbusinessnews.net/press-release/4dmedical-receives-ce-mark-for-ctvq-enabling-commercial-launch-across-the-european-union/) ![4DMedical receives CE Mark for CT:VQ™, enabling commercial launch across the European Union](https://i0.wp.com/mma.prnasia.com/media2/2944827/Lungs_Graphic_Cutouts_Color_BW.jpg?resize=260%2C140&ssl=1 "4DMedical receives CE Mark for CT:VQ™, enabling commercial launch across the European Union") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## 4DMedical receives CE Mark for CT:VQ™, enabling commercial launch across the European Union In a separate announcement made today, the Company also secured A$83 million… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - March 31, 2026 ##### Most Read - [![Visa Unveils Revised Singapore Security Roadmap to Strengthen Trust and Resilience in the AI Era](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/visa-unveils-revised-singapore-security-roadmap-to-strengthen-trust-and-resilience-in-the-ai-era/ "Visa Unveils Revised Singapore Security Roadmap to Strengthen Trust and Resilience in the AI Era") [Visa Unveils Revised Singapore Security Roadmap to Strengthen Trust and Resilience in the AI Era](https://thailandbusinessnews.net/press-release/visa-unveils-revised-singapore-security-roadmap-to-strengthen-trust-and-resilience-in-the-ai-era/ "Visa Unveils Revised Singapore Security Roadmap to Strengthen Trust and Resilience in the AI Era") - [![DETERMINANT UNVEILS FALL/WINTER 2026 COLLECTION WITH A NEW TAKE ON EVERYDAY CASUALWEAR](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/determinant-unveils-fall-winter-2026-collection-with-a-new-take-on-everyday-casualwear/ "DETERMINANT UNVEILS FALL/WINTER 2026 COLLECTION WITH A NEW TAKE ON EVERYDAY CASUALWEAR") [DETERMINANT UNVEILS FALL/WINTER 2026 COLLECTION WITH A NEW TAKE ON EVERYDAY CASUALWEAR](https://thailandbusinessnews.net/press-release/determinant-unveils-fall-winter-2026-collection-with-a-new-take-on-everyday-casualwear/ "DETERMINANT UNVEILS FALL/WINTER 2026 COLLECTION WITH A NEW TAKE ON EVERYDAY CASUALWEAR") - [![Trinasolar Vertex N Modules Selected for 562MWdc Dầu Tiếng 5 Floating Solar Project in Vietnam](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/trinasolar-vertex-n-modules-selected-for-562mwdc-dau-tieng-5-floating-solar-project-in-vietnam/ "Trinasolar Vertex N Modules Selected for 562MWdc Dầu Tiếng 5 Floating Solar Project in Vietnam") [Trinasolar Vertex N Modules Selected for 562MWdc Dầu Tiếng 5 Floating Solar Project in Vietnam](https://thailandbusinessnews.net/press-release/trinasolar-vertex-n-modules-selected-for-562mwdc-dau-tieng-5-floating-solar-project-in-vietnam/ "Trinasolar Vertex N Modules Selected for 562MWdc Dầu Tiếng 5 Floating Solar Project in Vietnam") - [![Agoda Spotlights Asia's Best "Skip-Gen" Destinations for Grandparents and Grandchildren Alike](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/agoda-spotlights-asias-best-skip-gen-destinations-for-grandparents-and-grandchildren-alike/ "Agoda Spotlights Asia's Best "Skip-Gen" Destinations for Grandparents and Grandchildren Alike") [Agoda Spotlights Asia's Best "Skip-Gen" Destinations for Grandparents and Grandchildren Alike](https://thailandbusinessnews.net/press-release/agoda-spotlights-asias-best-skip-gen-destinations-for-grandparents-and-grandchildren-alike/ "Agoda Spotlights Asia's Best "Skip-Gen" Destinations for Grandparents and Grandchildren Alike") - [![ThreatBook Accredited by IMDA Singapore for Full Cycle Agentic Cybersecurity Solutions](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/threatbook-accredited-by-imda-singapore-for-full-cycle-agentic-cybersecurity-solutions/ "ThreatBook Accredited by IMDA Singapore for Full Cycle Agentic Cybersecurity Solutions") [ThreatBook Accredited by IMDA Singapore for Full Cycle Agentic Cybersecurity Solutions](https://thailandbusinessnews.net/press-release/threatbook-accredited-by-imda-singapore-for-full-cycle-agentic-cybersecurity-solutions/ "ThreatBook Accredited by IMDA Singapore for Full Cycle Agentic Cybersecurity Solutions") - [![Why Hong Kong didn't follow the "doomsday scenarios" Western media had prefabricated](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/why-hong-kong-didnt-follow-the-doomsday-scenarios-western-media-had-prefabricated/ "Why Hong Kong didn't follow the "doomsday scenarios" Western media had prefabricated") [Why Hong Kong didn't follow the "doomsday scenarios" Western media had prefabricated](https://thailandbusinessnews.net/press-release/why-hong-kong-didnt-follow-the-doomsday-scenarios-western-media-had-prefabricated/ "Why Hong Kong didn't follow the "doomsday scenarios" Western media had prefabricated") ##### Subscribe via Email Enter your email address to subscribe and receive notifications of new posts by email. Email Address Subscribe [](https://thailandbusinessnews.net/press-release/activate-expands-down-under-with-first-australian-location-in-melbourne/) ## ACTIVATE EXPANDS DOWN UNDER WITH FIRST AUSTRALIAN LOCATION IN MELBOURNE WINNIPEG, MB, Sept. 10, 2026 /PRNewswire/ — Activate, North America’s… [](https://thailandbusinessnews.net/press-release/elegoo-day-2026-building-a-more-connected-ecosystem-where-ideas-become-real/) ![ELEGOO DAY 2026: Building a More Connected Ecosystem Where Ideas Become Real](https://i0.wp.com/mmx.prnasia.com/media/MS1985399/20260909211259EDT_image_1.jpg?resize=260%2C140&ssl=1 "ELEGOO DAY 2026: Building a More Connected Ecosystem Where Ideas Become Real") ## ELEGOO DAY 2026: Building a More Connected Ecosystem Where Ideas Become Real ELEGOO brings community together with the launch of its annual celebration, featuring… [](https://thailandbusinessnews.net/press-release/sacred-journeys-5-transport-leaders-connect-japans-ancient-pilgrimage-routes-to-offer-a-new-kind-of-travel/) ![Sacred Journeys: 5 Transport Leaders Connect Japan's Ancient Pilgrimage Routes to Offer a New Kind of Travel](https://i0.wp.com/mmx.prnasia.com/media/MS1985603/20260910043620EDT_image_1.jpg?resize=260%2C140&ssl=1 "Sacred Journeys: 5 Transport Leaders Connect Japan's Ancient Pilgrimage Routes to Offer a New Kind of Travel") ## Sacred Journeys: 5 Transport Leaders Connect Japan's Ancient Pilgrimage Routes to Offer a New Kind of Travel JR East, JR Central, JR West, JR Shikoku and JAL join forces… [](https://thailandbusinessnews.net/press-release/rision-magic-pro-now-available-for-pre-order-professional-grade-usb-c-thermal-imaging-in-your-pocket/) ![RISION Magic Pro Now Available for Pre-Order: Professional-Grade USB-C Thermal Imaging in Your Pocket](https://i0.wp.com/mmx.prnasia.com/media/MS1985681/20260910071106EDT_image_1.jpg?resize=260%2C140&ssl=1 "RISION Magic Pro Now Available for Pre-Order: Professional-Grade USB-C Thermal Imaging in Your Pocket") ## RISION Magic Pro Now Available for Pre-Order: Professional-Grade USB-C Thermal Imaging in Your Pocket Featuring AI dual-spectrum fusion, intelligent analysis, and instant reporting, the…