SynbioTech's L. plantarum FS4722 Emerges as a Potential Preventive Approach for Hyperuricemia - Thailand PR News - [Banking](https://thailandbusinessnews.net/category/banking/) - [Companies](https://thailandbusinessnews.net/category/companies/) - [Economy](https://thailandbusinessnews.net/category/economy/) - [Press Releases](https://thailandbusinessnews.net/category/press-release/) - [PR Newswire](https://thailandbusinessnews.net/pr-newswire-updates/) - [Tech](https://thailandbusinessnews.net/category/tech/) - [Tourism](https://thailandbusinessnews.net/category/tourism/) - [Press Release](https://thailandbusinessnews.net/category/press-release/) # SynbioTech's L. plantarum FS4722 Emerges as a Potential Preventive Approach for Hyperuricemia ##### Up next ![Taiwan's Smart Tolling Technology Goes Global as Thailand Launches AI-Powered M81 Motorway System](https://i0.wp.com/mma.prnasia.com/media2/2961639/1_______________M81.jpg?resize=200%2C110&ssl=1 "Taiwan's Smart Tolling Technology Goes Global as Thailand Launches AI-Powered M81 Motorway System") [](https://thailandbusinessnews.net/press-release/taiwans-smart-tolling-technology-goes-global-as-thailand-launches-ai-powered-m81-motorway-system/) ###### [Taiwan's Smart Tolling Technology Goes Global as Thailand Launches AI-Powered M81 Motorway System](https://thailandbusinessnews.net/press-release/taiwans-smart-tolling-technology-goes-global-as-thailand-launches-ai-powered-m81-motorway-system/) Published on 22 April 2026 ##### Author ##### [ CISION PRNewswire ](https://thailandbusinessnews.net/author/cision/) ##### Tags - [PRNewswire](https://thailandbusinessnews.net/tag/prnewswire/) TAIPEI, April 22, 2026 /PRNewswire/ — SynbioTech announced that its *Lactiplantibacillus plantarum* FS4722 (*L. plantarum* FS4722), a probiotic strain isolated from traditional Chinese pickled vegetables, has demonstrated potential to support urate regulation in hyperuricemia. *L. plantarum* FS4722 has shown synergistic effects in preclinical tests: lowering serum uric acid levels, limiting intestinal purine absorption, downregulating liver uric acid production, boosting excretion through the gut and kidneys, and rebalancing the gut microbiome and its metabolites. The finding was published in the field‑leading journal *Microbiome\** and was presented at the Asian Conference on Lactic Acid Bacteria (ACLAB 15), drawing international microbiologists from 17 countries, including the U.S., Japan, Singapore, South Korea, and Finland. **FS4722 Shows Drug-Like Uric Acid Control with Better Safety in Mice** Hyperuricemia, driven by disordered purine metabolism, is closely linked to gout, type 2 diabetes, kidney dysfunction, and hypertension, making it a rapidly growing global metabolic health concern. A 2022 *Scientific Reports* meta‑analysis pegged the global adult prevalence at 13.5%; Taiwan’s Nutrition and Health Survey (NAHSIT) found 22% among men and 9.7% among women. "Local diets and lifestyles heighten these risks today, making this highly relevant," said SynbioTech Chief Operating Officer Sean Yang. SynbioTech’s FS4722, a probiotic strain isolated from traditional Chinese pickled vegetables, offers a potential natural approach to support purine metabolism through the gut–liver–kidney axis, with the advantage of avoiding drug‑related kidney and cardiovascular side effects. The strain has become a focal point for both academic research and industrial development. **FS4722 Demonstrates Multi‑Mechanism Uric Acid Control in Preclinical Models** A Synbio Tech expert noted that purines derived from cellular metabolism and high‑purine foods can increase hepatic uric acid production, while non‑purine compounds may also indirectly contribute to uric acid formation through metabolic processes. In the preclinical mouse study, *L. plantarum* FS4722 targeted precursor uptake at the gut "source," where it reversed dysbiosis, promoted the growth of beneficial gut microbes, and increased short‑chain fatty acid production—offering an early intervention point in the diet–gut–uric acid chain. **FS4722 Lowers Uric Acid via the Gut–Liver–Kidney Axis** The study further revealed that, through the gut–liver–kidney axis, *L. plantarum* FS4722 reduces uric acid production in the liver, decreases the kidney’s reabsorption of uric acid, and enhances uric acid excretion from both the kidneys and the intestine. In experimental comparisons, *L. plantarum* FS4722 produced a reduction in hyperuricemia symptoms comparable to that of conventional uric acid–lowering drugs. However, unlike some pharmacological treatments, FS4722 did not cause evident impairment of kidney function or tissue‑pathological abnormalities, underscoring its favorable safety profile. Overall, *L. plantarum* FS4722 works through multiple pathways that suppress hepatic uric acid synthesis, enhance uric acid clearance, modulate gut microbiota and their metabolites, and limit intestinal absorption of uric acid precursors, supporting its potential as a preventive strategy for managing hyperuricemia and related metabolic risks. Founded in 2000, SynbioTech Group has grown into one of the leading global suppliers of probiotics, specializing in lactic acid bacteria applications and advanced probiotic R&D. Backed by proprietary fermentation and packaging platforms, the Taiwan‑based company has entered the supply chains of major manufacturers in the United States, Germany, South Korea, and Australia. SynbioTech has secured 60 patents, published more than 100 scientific papers—nearly half in international journals—and holds multiple overseas patents and international licensing agreements, with recent market expansion into Mainland China, Southeast Asia, Europe, the Americas, and Oceania. *\*Li, M., Wu, X., Guo, Z. et al. Lactiplantibacillus plantarum enables blood urate control in mice through degradation of nucleosides in gastrointestinal tract. Microbiome 11, 153 (2023).* Media Contact Rica Chiang PR Director of SynbioTech Group Email: [![The SynbioTech’s expert presented a study on FS4722 showing that the strain reduces intestinal absorption of uric acid precursors, suppresses hepatic uric acid production, and enhances uric acid excretion and gut microbiota modulation, offering a new preventive option for functional probiotics in hyperuricemia management.](https://mma.prnasia.com/media2/2961912/Image.jpg?p=medium600 "The SynbioTech’s expert presented a study on FS4722 showing that the strain reduces intestinal absorption of uric acid precursors, suppresses hepatic uric acid production, and enhances uric acid excretion and gut microbiota modulation, offering a new preventive option for functional probiotics in hyperuricemia management.")](https://mma.prnasia.com/media2/2961912/Image.html) The SynbioTech’s expert presented a study on FS4722 showing that the strain reduces intestinal absorption of uric acid precursors, suppresses hepatic uric acid production, and enhances uric acid excretion and gut microbiota modulation, offering a new preventive option for functional probiotics in hyperuricemia management. [Source link ](http://www.prnasia.com/story/archive/4939520_AE39520_0?rand=89749) ``` This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network ``` ##### You May Also Like [](https://thailandbusinessnews.net/press-release/bri-prepares-rp3-trillion-for-share-buyback-to-sustain-long-term-performance/) ![BRI Prepares Rp3 Trillion for Share Buyback to Sustain Long-Term Performance](https://i0.wp.com/r2.thailandbusinessnews.net/2025/04/PT_Bank_Rakyat_Indonesia_Tbk_BRImo.jpg?resize=260%2C140&ssl=1 "BRI Prepares Rp3 Trillion for Share Buyback to Sustain Long-Term Performance") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## BRI Prepares Rp3 Trillion for Share Buyback to Sustain Long-Term Performance JAKARTA, Indonesia, April 14, 2025 /PRNewswire/ — PT Bank Rakyat Indonesia (Persero)… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - April 14, 2025 [](https://thailandbusinessnews.net/press-release/heybike-x-series-mars-3-0-ranger-3-0-pro-redefining-ebike-excellence/) ![Heybike X Series Mars 3.0 & Ranger 3.0 Pro: Redefining Ebike Excellence](https://i0.wp.com/r2.thailandbusinessnews.net/2025/08/Heybike_X_Series.jpg?resize=260%2C140&ssl=1 "Heybike X Series Mars 3.0 & Ranger 3.0 Pro: Redefining Ebike Excellence") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## Heybike X Series Mars 3.0 & Ranger 3.0 Pro: Redefining Ebike Excellence LOS ANGELES, Aug. 6, 2025 /PRNewswire/ — Heybike is thrilled to unveil… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - August 6, 2025 [](https://thailandbusinessnews.net/press-release/surplusglobal-to-launch-beta-of-semiconductor-equipment-and-parts-platform-semimarket-www-semimarket-com-on-june-2-with-grand-opening-planned-for-december/) ![SurplusGLOBAL to Launch Beta of Semiconductor Equipment and Parts Platform 'SemiMarket (www.SemiMarket.com)' on June 2, with Grand Opening Planned for December](https://i0.wp.com/r2.thailandbusinessnews.net/2025/06/250605_SemiMarket_Open_BETA_version.jpg?resize=260%2C140&ssl=1 "SurplusGLOBAL to Launch Beta of Semiconductor Equipment and Parts Platform 'SemiMarket (www.SemiMarket.com)' on June 2, with Grand Opening Planned for December") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## SurplusGLOBAL to Launch Beta of Semiconductor Equipment and Parts Platform 'SemiMarket (www.SemiMarket.com)' on June 2, with Grand Opening Planned for December SEOUL, South Korea, June 10, 2025 /PRNewswire/ — SurplusGLOBAL, a leading provider… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - June 10, 2025 ##### Most Read - [![2026 Beijing International Week for Science Literacy Launched in Beijing](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/2026-beijing-international-week-for-science-literacy-launched-in-beijing/ "2026 Beijing International Week for Science Literacy Launched in Beijing") [2026 Beijing International Week for Science Literacy Launched in Beijing](https://thailandbusinessnews.net/press-release/2026-beijing-international-week-for-science-literacy-launched-in-beijing/ "2026 Beijing International Week for Science Literacy Launched in Beijing") - [![iQIYI at the Shanghai TV Festival: Shaping the future of content with premium storytelling, AI, and global expansion](https://i0.wp.com/r2.thailandbusinessnews.net/2025/06/Xiao_CHEN_Senior_Vice_President_iQIYI.jpg?fit=599%2C401&ssl=1&resize=40%2C40)](https://thailandbusinessnews.net/press-release/iqiyi-at-the-shanghai-tv-festival-shaping-the-future-of-content-with-premium-storytelling-ai-and-global-expansion/ "iQIYI at the Shanghai TV Festival: Shaping the future of content with premium storytelling, AI, and global expansion") [iQIYI at the Shanghai TV Festival: Shaping the future of content with premium storytelling, AI, and global expansion](https://thailandbusinessnews.net/press-release/iqiyi-at-the-shanghai-tv-festival-shaping-the-future-of-content-with-premium-storytelling-ai-and-global-expansion/ "iQIYI at the Shanghai TV Festival: Shaping the future of content with premium storytelling, AI, and global expansion") - [![Power Transmission in Full Swing at the Infrastructure Site Amid Heavy Snowfall](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/power-transmission-in-full-swing-at-the-infrastructure-site-amid-heavy-snowfall/ "Power Transmission in Full Swing at the Infrastructure Site Amid Heavy Snowfall") [Power Transmission in Full Swing at the Infrastructure Site Amid Heavy Snowfall](https://thailandbusinessnews.net/press-release/power-transmission-in-full-swing-at-the-infrastructure-site-amid-heavy-snowfall/ "Power Transmission in Full Swing at the Infrastructure Site Amid Heavy Snowfall") - [![Eventify Unveils Event AI Copilot To Boost Attendee Experience](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/eventify-unveils-event-ai-copilot-to-boost-attendee-experience/ "Eventify Unveils Event AI Copilot To Boost Attendee Experience") [Eventify Unveils Event AI Copilot To Boost Attendee Experience](https://thailandbusinessnews.net/press-release/eventify-unveils-event-ai-copilot-to-boost-attendee-experience/ "Eventify Unveils Event AI Copilot To Boost Attendee Experience") - [![Amaran Biotech's Vaccine Adjuvant AB-801 Receives FDA Drug Master File (DMF) Filing Acknowledgement](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/amaran-biotechs-vaccine-adjuvant-ab-801-receives-fda-drug-master-file-dmf-filing-acknowledgement/ "Amaran Biotech's Vaccine Adjuvant AB-801 Receives FDA Drug Master File (DMF) Filing Acknowledgement") [Amaran Biotech's Vaccine Adjuvant AB-801 Receives FDA Drug Master File (DMF) Filing Acknowledgement](https://thailandbusinessnews.net/press-release/amaran-biotechs-vaccine-adjuvant-ab-801-receives-fda-drug-master-file-dmf-filing-acknowledgement/ "Amaran Biotech's Vaccine Adjuvant AB-801 Receives FDA Drug Master File (DMF) Filing Acknowledgement") - [![NWTN and Pakistan's JW Corporation Enter New Energy Commercial Vehicle Production Partnership, Implementing "UAE HQ + South Asia Manufacturing + Global Sales" Strategy](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/nwtn-and-pakistans-jw-corporation-enter-new-energy-commercial-vehicle-production-partnership-implementing-uae-hq-south-asia-manufacturing-global-sales-strategy/ "NWTN and Pakistan's JW Corporation Enter New Energy Commercial Vehicle Production Partnership, Implementing "UAE HQ + South Asia Manufacturing + Global Sales" Strategy") [NWTN and Pakistan's JW Corporation Enter New Energy Commercial Vehicle Production Partnership, Implementing "UAE HQ + South Asia Manufacturing + Global Sales" Strategy](https://thailandbusinessnews.net/press-release/nwtn-and-pakistans-jw-corporation-enter-new-energy-commercial-vehicle-production-partnership-implementing-uae-hq-south-asia-manufacturing-global-sales-strategy/ "NWTN and Pakistan's JW Corporation Enter New Energy Commercial Vehicle Production Partnership, Implementing "UAE HQ + South Asia Manufacturing + Global Sales" Strategy") ##### Subscribe via Email Enter your email address to subscribe and receive notifications of new posts by email. Email Address Subscribe [](https://thailandbusinessnews.net/press-release/ai-memory-storage-the-5th-gmif2026-innovation-summit-successfully-concludes-in-shenzhen/) ![AI Memory & Storage: The 5th GMIF2026 Innovation Summit Successfully Concludes in Shenzhen](https://i0.wp.com/mmx.prnasia.com/media/MS1996920/20260926103342EDT_image_1.jpg?resize=260%2C140&ssl=1 "AI Memory & Storage: The 5th GMIF2026 Innovation Summit Successfully Concludes in Shenzhen") ## AI Memory & Storage: The 5th GMIF2026 Innovation Summit Successfully Concludes in Shenzhen SHENZHEN, China, Sept. 26, 2026 /PRNewswire/ — On September 23, the 5th… [](https://thailandbusinessnews.net/press-release/2026-beijing-international-week-for-science-literacy-launched-in-beijing/) ![2026 Beijing International Week for Science Literacy Launched in Beijing](https://i0.wp.com/mmx.prnasia.com/media/MS1996957/20260927001808EDT_image_1.jpg?resize=260%2C140&ssl=1 "2026 Beijing International Week for Science Literacy Launched in Beijing") ## 2026 Beijing International Week for Science Literacy Launched in Beijing BEIJING, Sept. 27, 2026 /PRNewswire/ — The 2026 Beijing International Week for… [](https://thailandbusinessnews.net/press-release/2026-ims-iaso-bio-presented-fucaso-china-real-world-data/) ## 2026 IMS | IASO Bio Presented FUCASO China Real-World Data — In a large China real-world study of 281 heavily pretreated, predominantly… [](https://thailandbusinessnews.net/press-release/2026-ims-iaso-bio-presented-first-in-human-data-of-bcma-targeted-in-vivo-car-t-cell-therapy-iaso206/) ## 2026 IMS | IASO Bio Presented First-in-Human Data of BCMA-Targeted In Vivo CAR-T Cell Therapy IASO206 — Late-breaking oral presentation of first-in-human data (LBA-11) showed that a single…