NUS researchers boost chemotherapy uptake in breast cancer treatment with localised magnetic fields - Thailand PR News - [Banking](https://thailandbusinessnews.net/category/banking/) - [Companies](https://thailandbusinessnews.net/category/companies/) - [Economy](https://thailandbusinessnews.net/category/economy/) - [Press Releases](https://thailandbusinessnews.net/category/press-release/) - [PR Newswire](https://thailandbusinessnews.net/pr-newswire-updates/) - [Tech](https://thailandbusinessnews.net/category/tech/) - [Tourism](https://thailandbusinessnews.net/category/tourism/) - [Press Release](https://thailandbusinessnews.net/category/press-release/) # NUS researchers boost chemotherapy uptake in breast cancer treatment with localised magnetic fields ##### Up next ![HDMI FORUM ANNOUNCES VERSION 2.2 OF THE HDMI SPECIFICATION](https://i0.wp.com/r2.thailandbusinessnews.net/2025/01/Ultra96_HDMI_Cable.jpg?resize=200%2C110&ssl=1 "HDMI FORUM ANNOUNCES VERSION 2.2 OF THE HDMI SPECIFICATION") [](https://thailandbusinessnews.net/press-release/hdmi-forum-announces-version-2-2-of-the-hdmi-specification/) ###### [HDMI FORUM ANNOUNCES VERSION 2.2 OF THE HDMI SPECIFICATION](https://thailandbusinessnews.net/press-release/hdmi-forum-announces-version-2-2-of-the-hdmi-specification/) Published on 07 January 2025 ##### Author ##### [ CISION PRNewswire ](https://thailandbusinessnews.net/author/cision/) ![](https://mma.prnasia.com/media2/291548/national_university_of_singapore_logo.jpg?p=medium600 "logo") A recent study explained the mechanisms by which pulsed electromagnetic field therapy enhances doxorubicin uptake, paving the way for precision-driven cancer therapies with fewer side effects SINGAPORE, Jan. 7, 2025 /PRNewswire/ — Researchers at the National University of Singapore (NUS) have developed a non-invasive method to improve the effectiveness of chemotherapy while reducing its harmful side effects. By applying brief, localised pulses of magnetic fields, the team demonstrated a significant increase in the uptake of doxorubicin (DOX), a widely used chemotherapy drug, into breast cancer cells, with minimal impact on healthy tissues. This selective uptake enables more precise targeting of cancer cells, potentially improving treatment outcomes and reducing the adverse effects often associated with chemotherapy. The study, led by Associate Professor Alfredo Franco-Obregón, Principal Investigator at the [Institute for Health Innovation & Technology](https://ihealthtech.nus.edu.sg/) (iHealthtech) at NUS and faculty member of the Department of Surgery at [NUS Yong Loo Lin School of Medicine](https://medicine.nus.edu.sg/) (NUS Medicine), is the first to systematically show how pulsed magnetic fields enhance DOX uptake in cancer cells. The team also showed that this approach could suppress tumours at lower drug doses. The team’s research was published in the journal [Cancers](https://www.mdpi.com/2072-6694/16/22/3860) on 18 November 2024. It builds on earlier work from [2022](https://news.nus.edu.sg/magnetic-therapy-enhances-chemotherapy-treatment-of-breast-cancer), which first revealed that certain cancer cells are more vulnerable to magnetic field therapy. Targeted therapy for better chemotherapy outcomes and fewer side effects DOX is a commonly used chemotherapy drug for breast cancer. It works by binding to DNA components and disrupting cell replication and respiration, which then kills off cancer cells. Despite its efficacy, it is a non-selective drug, which means it can also damage healthy tissues, leading to side effects ranging from mild to severe, including cardiomyopathy and muscle atrophy. To address these challenges, the NUS researchers developed a novel approach that uses brief pulses of magnetic fields to selectively increase DOX uptake into breast cancer cells. Their study revealed the role of a calcium ion channel known as TRPC1, which is often found in aggressive cancers, including breast cancer. Magnetic field exposure activates TRPC1, enhancing its ability to facilitate the entry of DOX into cancer cells. The researchers conducted experiments comparing the effects of the magnetic field therapy on human breast cancer cells and healthy muscle cells. They found that breast cancer cells took in significantly more DOX when exposed to magnetic pulses, while normal tissues were not targeted as much. A 10-minute magnetic field exposure reduced the drug concentration needed for similar amount of cancer killing by half, particularly at low doses of the drug. In contrast, healthy muscle cells did not show an increase in cell death in response to the combination of DOX and magnetic pulses indicating greater protection for non-cancerous tissues. The team also demonstrated that reducing TRPC1 expression or blocking its activity eliminated this effect, which confirms the crucial role of TRPC1 channels in the process. "Importantly, when we increased the amount of TRPC1, we observed an increase in DOX uptake — this means that TRPC1 can be used as a viable therapeutic target for aggressive cancers," said Mr Viresh Krishnan Sukumar, the paper’s first author and a PhD candidate at NUS Centre for Cancer Research (N2CR) under NUS Yong Loo Lin School of Medicine. "What’s promising is that this mechanism works strongest at low drug concentrations, enabling us to target cancer cells more effectively while reducing the burden of chemotherapy on healthy tissues," Assoc Prof Franco-Obregón added. With breast cancer remaining the leading cause of cancer-related deaths among women worldwide, the need for novel treatment strategies is urgent. "The majority of women who undergo chemotherapy experience side effects from treatment, and in some cases, doses of chemotherapy need to be reduced, or in severe cases, stopped prematurely," said research team member Assistant Professor Joline Lim, Principal Investigator at N2CR and Senior Consultant, Department of Haematology-Oncology, National University Cancer Institute, Singapore. "Moreover, prolonged exposure to high-dose chemotherapy can also lead to drug resistance. This targeted approach represents an excellent opportunity to potentially improve treatment outcomes while preserving patients’ quality of life." Advancing the frontier of precision oncology The team’s magnetic-assisted approach addresses one of the biggest challenges of chemotherapy, namely its toxic effects on healthy tissues. By selectively enhancing drug uptake into cancer cells, this method has the potential to drastically reduce the systemic side effects often experienced by breast cancer patients. This not only improves treatment outcomes and quality of life, but also encourages earlier treatment for those hesitant about treatment side effects. The study also underscores the role of biomarkers, such as elevated TRPC1 expression, in transforming cancer care by enabling precision-driven treatment options. Future work will focus on translating these findings into clinical practice by localising magnetic field exposure specifically to tumours in patients. This would further validate the potential to reduce systemic DOX doses while maximising localised drug delivery in cancer cells. "Our approach will be patented and form the foundation for a startup specialising in breast cancer treatment. We are currently in discussions with potential investors in Southeast Asia and the United States to translate this technology from bench to bedside," shared Assoc Prof Franco-Obregón. Read more at: [Source link ](https://www.prnasia.com/story/archive/4589348_CN89348_0?rand=89749) ``` This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network ``` ##### You May Also Like [](https://thailandbusinessnews.net/press-release/automation-anywhere-announces-availability-of-agents-in-the-new-aws-marketplace-ai-agents-and-tools-category/) ## Automation Anywhere Announces Availability of Agents in the New AWS Marketplace AI Agents and Tools Category NEW YORK, July 17, 2025 /PRNewswire/ — At AWS Summit New York City, Automation… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - July 17, 2025 [](https://thailandbusinessnews.net/press-release/hecto-media-launches-ai-powered-multilingual-k-culture-platform-k-snapp/) ![Hecto Media Launches AI-Powered Multilingual K-Culture Platform, 'K-snapp'](https://i0.wp.com/mma.prnasia.com/media2/2853163/K_snapp_Photo__Image_generated_by_AI.jpg?resize=260%2C140&ssl=1 "Hecto Media Launches AI-Powered Multilingual K-Culture Platform, 'K-snapp'") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## Hecto Media Launches AI-Powered Multilingual K-Culture Platform, 'K-snapp' Real-time, AI-driven multilingual delivery of K-entertainment news to expand global fan engagement… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - December 31, 2025 [](https://thailandbusinessnews.net/press-release/tvu-networks-joins-aws-isv-accelerate-program-strengthening-cloud-based-live-media-innovation/) ![TVU Networks Joins AWS ISV Accelerate Program, Strengthening Cloud-Based Live Media Innovation](https://i0.wp.com/r2.thailandbusinessnews.net/2025/04/Linkedin_TVU_AWS.jpg?resize=260%2C140&ssl=1 "TVU Networks Joins AWS ISV Accelerate Program, Strengthening Cloud-Based Live Media Innovation") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## TVU Networks Joins AWS ISV Accelerate Program, Strengthening Cloud-Based Live Media Innovation CUPERTINO, Calif., April 4, 2025 /PRNewswire/ — TVU Networks, a leader in… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - April 4, 2025 ##### Most Read - [![NYSE Honors Victims of 9/11: NYSE Content Update](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/nyse-honors-victims-of-9-11-nyse-content-update/ "NYSE Honors Victims of 9/11: NYSE Content Update") [NYSE Honors Victims of 9/11: NYSE Content Update](https://thailandbusinessnews.net/press-release/nyse-honors-victims-of-9-11-nyse-content-update/ "NYSE Honors Victims of 9/11: NYSE Content Update") - [![When AI Learns to Defend Itself: Edvance International, CWG Innovations and RealRelay Rewrite Agent Security](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/when-ai-learns-to-defend-itself-edvance-international-cwg-innovations-and-realrelay-rewrite-agent-security/ "When AI Learns to Defend Itself: Edvance International, CWG Innovations and RealRelay Rewrite Agent Security") [When AI Learns to Defend Itself: Edvance International, CWG Innovations and RealRelay Rewrite Agent Security](https://thailandbusinessnews.net/press-release/when-ai-learns-to-defend-itself-edvance-international-cwg-innovations-and-realrelay-rewrite-agent-security/ "When AI Learns to Defend Itself: Edvance International, CWG Innovations and RealRelay Rewrite Agent Security") - [![LOTTE HOTELS & RESORTS Launches Exclusive Travel Pass Featuring Limited-Edition Korean Heritage Transit Cards](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/lotte-hotels-resorts-launches-exclusive-travel-pass-featuring-limited-edition-korean-heritage-transit-cards/ "LOTTE HOTELS & RESORTS Launches Exclusive Travel Pass Featuring Limited-Edition Korean Heritage Transit Cards") [LOTTE HOTELS & RESORTS Launches Exclusive Travel Pass Featuring Limited-Edition Korean Heritage Transit Cards](https://thailandbusinessnews.net/press-release/lotte-hotels-resorts-launches-exclusive-travel-pass-featuring-limited-edition-korean-heritage-transit-cards/ "LOTTE HOTELS & RESORTS Launches Exclusive Travel Pass Featuring Limited-Edition Korean Heritage Transit Cards") - [![Earth Environmental Foundation's Western Sichuan "Resilience & Symbiosis" Interdisciplinary Field Study Camp Sharing Session Inspires Youth on Climate Resilience and Ecological Symbiosis](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/earth-environmental-foundations-western-sichuan-resilience-symbiosis-interdisciplinary-field-study-camp-sharing-session-inspires-youth-on-climate-resilience-and-ecological-symb/ "Earth Environmental Foundation's Western Sichuan "Resilience & Symbiosis" Interdisciplinary Field Study Camp Sharing Session Inspires Youth on Climate Resilience and Ecological Symbiosis") [Earth Environmental Foundation's Western Sichuan "Resilience & Symbiosis" Interdisciplinary Field Study Camp Sharing Session Inspires Youth on Climate Resilience and Ecological Symbiosis](https://thailandbusinessnews.net/press-release/earth-environmental-foundations-western-sichuan-resilience-symbiosis-interdisciplinary-field-study-camp-sharing-session-inspires-youth-on-climate-resilience-and-ecological-symb/ "Earth Environmental Foundation's Western Sichuan "Resilience & Symbiosis" Interdisciplinary Field Study Camp Sharing Session Inspires Youth on Climate Resilience and Ecological Symbiosis") - [![Meritz Securities Connects to Bruce Markets' Data Feed for U.S. Equities, Improving Market Data for Korean Traders](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/meritz-securities-connects-to-bruce-markets-data-feed-for-u-s-equities-improving-market-data-for-korean-traders/ "Meritz Securities Connects to Bruce Markets' Data Feed for U.S. Equities, Improving Market Data for Korean Traders") [Meritz Securities Connects to Bruce Markets' Data Feed for U.S. Equities, Improving Market Data for Korean Traders](https://thailandbusinessnews.net/press-release/meritz-securities-connects-to-bruce-markets-data-feed-for-u-s-equities-improving-market-data-for-korean-traders/ "Meritz Securities Connects to Bruce Markets' Data Feed for U.S. Equities, Improving Market Data for Korean Traders") - [![Vitafoods Asia Announces Strategic Move to Kuala Lumpur for 2027 Edition](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/vitafoods-asia-announces-strategic-move-to-kuala-lumpur-for-2027-edition/ "Vitafoods Asia Announces Strategic Move to Kuala Lumpur for 2027 Edition") [Vitafoods Asia Announces Strategic Move to Kuala Lumpur for 2027 Edition](https://thailandbusinessnews.net/press-release/vitafoods-asia-announces-strategic-move-to-kuala-lumpur-for-2027-edition/ "Vitafoods Asia Announces Strategic Move to Kuala Lumpur for 2027 Edition") ##### Subscribe via Email Enter your email address to subscribe and receive notifications of new posts by email. Email Address Subscribe [](https://thailandbusinessnews.net/press-release/royal-caribbean-names-retired-u-s-air-force-gen-lori-j-robinson-godmother-of-legend-of-the-seas/) ![ROYAL CARIBBEAN NAMES RETIRED U.S. AIR FORCE GEN. LORI J. ROBINSON GODMOTHER OF LEGEND OF THE SEAS](https://i0.wp.com/mmx.prnasia.com/media/MS1987678/Royal-Caribbean-Gen-Lori-Robinson.jpg?resize=260%2C140&ssl=1 "ROYAL CARIBBEAN NAMES RETIRED U.S. AIR FORCE GEN. LORI J. ROBINSON GODMOTHER OF LEGEND OF THE SEAS") ## ROYAL CARIBBEAN NAMES RETIRED U.S. AIR FORCE GEN. LORI J. ROBINSON GODMOTHER OF LEGEND OF THE SEAS The trailblazing leader will celebrate the U.S. arrival of the vacation brand’s… [](https://thailandbusinessnews.net/press-release/artprice-news-the-18th-lyon-biennale-of-contemporary-art-is-now-open/) ![ARTPRICE NEWS: THE 18TH LYON BIENNALE OF CONTEMPORARY ART IS NOW OPEN](https://i0.wp.com/mmx.prnasia.com/media/MS1982962/LOGO-labiennaledelyon.jpg?resize=260%2C140&ssl=1 "ARTPRICE NEWS: THE 18TH LYON BIENNALE OF CONTEMPORARY ART IS NOW OPEN") ## ARTPRICE NEWS: THE 18TH LYON BIENNALE OF CONTEMPORARY ART IS NOW OPEN Passer d’un rêve à l’autre — Passing from One Dream to Another… [](https://thailandbusinessnews.net/press-release/kiwibit-launches-bird-feeder-2-pro-the-worlds-first-smart-bird-feeder-with-4k-hdr-and-auto-focus/) ![Kiwibit Launches Bird Feeder 2 Pro, the World's First Smart Bird Feeder with 4K HDR and Auto-Focus](https://i0.wp.com/mmx.prnasia.com/media/MS1988657/20260915075640EDT_image_1.jpg?resize=260%2C140&ssl=1 "Kiwibit Launches Bird Feeder 2 Pro, the World's First Smart Bird Feeder with 4K HDR and Auto-Focus") ## Kiwibit Launches Bird Feeder 2 Pro, the World's First Smart Bird Feeder with 4K HDR and Auto-Focus IRVINE, Calif., Sept. 15, 2026 /PRNewswire/ — Kiwibit today unveiled Kiwibit Bird… [](https://thailandbusinessnews.net/press-release/vevor-monthly-power-15-returns-september-15-18-powering-fall-home-preparation/) ![VEVOR Monthly Power 15 Returns September 15-18, Powering Fall Home Preparation](https://i0.wp.com/mmx.prnasia.com/media/MS1988561/20260915042852EDT_image_1.jpg?resize=260%2C140&ssl=1 "VEVOR Monthly Power 15 Returns September 15-18, Powering Fall Home Preparation") ## VEVOR Monthly Power 15 Returns September 15-18, Powering Fall Home Preparation As the season turns and project lists shift indoors, VEVOR’s recurring monthly…