FDA Approved Phase II/III Clinical Study of KPG-121 in Combination with Abiraterone as a First Line Treatment for mCRPC - Thailand PR News - [Banking](https://thailandbusinessnews.net/category/banking/) - [Companies](https://thailandbusinessnews.net/category/companies/) - [Economy](https://thailandbusinessnews.net/category/economy/) - [Press Releases](https://thailandbusinessnews.net/category/press-release/) - [PR Newswire](https://thailandbusinessnews.net/pr-newswire-updates/) - [Tech](https://thailandbusinessnews.net/category/tech/) - [Tourism](https://thailandbusinessnews.net/category/tourism/) - [Press Release](https://thailandbusinessnews.net/category/press-release/) # FDA Approved Phase II/III Clinical Study of KPG-121 in Combination with Abiraterone as a First Line Treatment for mCRPC ##### Up next ![State Grid Shandong Jining Sishui County Power Supply Company: "Busy Farming Season Ensures Power Reliability"](https://i0.wp.com/thailandbusinessnews.net/wp-content/uploads/2023/10/SSampC-Completes-Acquisition-of-Iress039-Managed-Funds-Administration-Business.jpg?resize=200%2C110&ssl=1 "State Grid Shandong Jining Sishui County Power Supply Company: "Busy Farming Season Ensures Power Reliability"") [](https://thailandbusinessnews.net/press-release/state-grid-shandong-jining-sishui-county-power-supply-company-busy-farming-season-ensures-power-reliability/) ###### [State Grid Shandong Jining Sishui County Power Supply Company: "Busy Farming Season Ensures Power Reliability"](https://thailandbusinessnews.net/press-release/state-grid-shandong-jining-sishui-county-power-supply-company-busy-farming-season-ensures-power-reliability/) Published on 05 June 2024 ##### Author ##### [ CISION PRNewswire ](https://thailandbusinessnews.net/author/cision/) ##### Tags - [PRNewswire](https://thailandbusinessnews.net/tag/prnewswire/) ![](https://mma.prnasia.com/media2/2195271/image_5006115_32782283_Logo.jpg?p=medium600 "logo") HEFEI, China, June 5, 2024 /PRNewswire/ — Kangpu Biopharmaceuticals today announced that the U.S. Food and Drug Administration (FDA) has recently approved a Phase II/III clinical trial of KPG-121 in combination with Abiraterone for a first-line treatment of metastatic castration resistant prostate cancer (mCRPC). Discovered by Kangpu Biopharmaceuticals, KPG-121 is a modulator of the Cereblon (CRBN) E3 ubiquitin ligase complex CRL4CRBN targeting rapid ubiquitination and degradation of casein kinase 1α (CK1α) and transcription factors Aiolos (IKZF3) and Ikaros (IKZF1). KPG-121 promotes anti-proliferation and anti-angiogenesis activities and enhances immunomodulatory properties. KPG-121 significantly improves anti-tumor efficacies when combined with androgen-receptor antagonists including enzalutamide, abiraterone acetate, apalutamide, or darolutamide in xenograft models when compared to the androgen-receptor antagonist therapy alone. A Phase I study to evaluate the safety, pharmacokinetics, and efficacy of KPG-121 when combined with enzalutamide, abiraterone, or apalutamide for the treatment of patients with metastatic or non-metastatic castration-resistant prostate cancer was completed in the US (NCT03569280). KPG-121 was generally well tolerated and demonstrated a favorable pharmacokinetic profile as well as promising efficacy. About Kangpu Biopharmaceuticals Kangpu Biopharmaceuticals, Ltd. is a clinical-stage company focused on the discovery and development of innovative small molecules for the treatment of solid tumors, hematologic malignancies, autoimmune diseases, and inflammatory disorders through novel solutions, including targeted protein ubiquitination and degradation. Kangpu has developed a robust pipeline of potential first-in-class and best-in-class drug candidates based on proprietary technology platforms, including NeoMIDES®, gDACs®, and X-SYNERGY®. For more information, please visit [www.KangpuGroup.com](https://www.KangpuGroup.com). Contact: Florence Liu [Source link ](https://www.prnasia.com/story/archive/4432046_CN32046_0?rand=89749) ``` This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network ``` ##### You May Also Like [](https://thailandbusinessnews.net/press-release/this-summers-next-trend-stationery-says-yiwugo/) ![This Summer's Next Trend? Stationery, Says Yiwugo](https://i0.wp.com/thailandbusinessnews.net/wp-content/uploads/2025/08/2025_08_16_065951_935.jpg?resize=260%2C140&ssl=1 "This Summer's Next Trend? Stationery, Says Yiwugo") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## This Summer's Next Trend? Stationery, Says Yiwugo YIWU, China, Aug. 17, 2025 /PRNewswire/ — Yiwugo.com, the official website of… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - August 17, 2025 [](https://thailandbusinessnews.net/press-release/tequila-enemigo-announces-long-term-partnership-with-fulham-football-club-the-first-ever-tequila-partner-of-an-english-premier-league-team/) ## Tequila Enemigo Announces Long-Term Partnership with Fulham Football Club – The First Ever Tequila Partner of an English Premier League Team In a historic partnership with Fulham Football Club, Tequila Enemigo becomes the… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - October 22, 2024 [](https://thailandbusinessnews.net/press-release/amtd-owner-of-lofficiel-and-amtd-idea-brands-launches-litigation-against-jalou-family-for-malicious-falsehood-defamation-and-consequential-loss-and-damage/) ## AMTD, Owner of L'Officiel and AMTD IDEA Brands, Launches Litigation against Jalou Family for Malicious Falsehood, Defamation, and Consequential Loss and Damage PARIS, LONDON and NEW YORK, Jan. 15, 2026 /PRNewswire/ — AMTD Group… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - January 15, 2026 ##### Most Read - [![CMC REIT Steadily Advances Strategic Transformation in 2026 Interim Results](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/cmc-reit-steadily-advances-strategic-transformation-in-2026-interim-results/ "CMC REIT Steadily Advances Strategic Transformation in 2026 Interim Results") [CMC REIT Steadily Advances Strategic Transformation in 2026 Interim Results](https://thailandbusinessnews.net/press-release/cmc-reit-steadily-advances-strategic-transformation-in-2026-interim-results/ "CMC REIT Steadily Advances Strategic Transformation in 2026 Interim Results") - [![UOB Poll Finds SMEs Keen on AI but Struggle to Move Beyond Pilot Stage](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/uob-poll-finds-smes-keen-on-ai-but-struggle-to-move-beyond-pilot-stage/ "UOB Poll Finds SMEs Keen on AI but Struggle to Move Beyond Pilot Stage") [UOB Poll Finds SMEs Keen on AI but Struggle to Move Beyond Pilot Stage](https://thailandbusinessnews.net/press-release/uob-poll-finds-smes-keen-on-ai-but-struggle-to-move-beyond-pilot-stage/ "UOB Poll Finds SMEs Keen on AI but Struggle to Move Beyond Pilot Stage") - [![Joget Introduces Agent Lab, a Program Helping Businesses Build AI Agents Without Code](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/joget-introduces-agent-lab-a-program-helping-businesses-build-ai-agents-without-code/ "Joget Introduces Agent Lab, a Program Helping Businesses Build AI Agents Without Code") [Joget Introduces Agent Lab, a Program Helping Businesses Build AI Agents Without Code](https://thailandbusinessnews.net/press-release/joget-introduces-agent-lab-a-program-helping-businesses-build-ai-agents-without-code/ "Joget Introduces Agent Lab, a Program Helping Businesses Build AI Agents Without Code") - [![Russell Reynolds Associates Announces Nick Fletcher as Australia Country Leader](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/russell-reynolds-associates-announces-nick-fletcher-as-australia-country-leader/ "Russell Reynolds Associates Announces Nick Fletcher as Australia Country Leader") [Russell Reynolds Associates Announces Nick Fletcher as Australia Country Leader](https://thailandbusinessnews.net/press-release/russell-reynolds-associates-announces-nick-fletcher-as-australia-country-leader/ "Russell Reynolds Associates Announces Nick Fletcher as Australia Country Leader") - [![Hyundai Motor Company Charts Profit-Driven Growth Roadmap at 2026 CEO Investor Day](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/hyundai-motor-company-charts-profit-driven-growth-roadmap-at-2026-ceo-investor-day/ "Hyundai Motor Company Charts Profit-Driven Growth Roadmap at 2026 CEO Investor Day") [Hyundai Motor Company Charts Profit-Driven Growth Roadmap at 2026 CEO Investor Day](https://thailandbusinessnews.net/press-release/hyundai-motor-company-charts-profit-driven-growth-roadmap-at-2026-ceo-investor-day/ "Hyundai Motor Company Charts Profit-Driven Growth Roadmap at 2026 CEO Investor Day") - [![Voltage Energy Will Seek New Trial and Review of Verdict in Shoals Patent Dispute](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/voltage-energy-will-seek-new-trial-and-review-of-verdict-in-shoals-patent-dispute/ "Voltage Energy Will Seek New Trial and Review of Verdict in Shoals Patent Dispute") [Voltage Energy Will Seek New Trial and Review of Verdict in Shoals Patent Dispute](https://thailandbusinessnews.net/press-release/voltage-energy-will-seek-new-trial-and-review-of-verdict-in-shoals-patent-dispute/ "Voltage Energy Will Seek New Trial and Review of Verdict in Shoals Patent Dispute") ##### Subscribe via Email Enter your email address to subscribe and receive notifications of new posts by email. Email Address Subscribe [](https://thailandbusinessnews.net/press-release/tutti-vm-launches-in-early-access-the-google-docs-moment-for-cross-agent-collaboration/) ![Tutti • VM Launches in Early Access: The Google Docs Moment for Cross-Agent Collaboration](https://i0.wp.com/mmx.prnasia.com/media/MS1973504/20260821015411EDT_image_3.jpg?resize=260%2C140&ssl=1 "Tutti • VM Launches in Early Access: The Google Docs Moment for Cross-Agent Collaboration") ## Tutti • VM Launches in Early Access: The Google Docs Moment for Cross-Agent Collaboration Local agents stay local and identity never leaves the machine, while multi-layer… [](https://thailandbusinessnews.net/press-release/msi-xpertstation-ws300-based-on-nvidia-dgx-station-now-available/) ![MSI XpertStation WS300 Based on NVIDIA DGX Station Now Available](https://i0.wp.com/mmx.prnasia.com/media/MS1976770/20260827011923EDT_image_1.jpg?resize=260%2C140&ssl=1 "MSI XpertStation WS300 Based on NVIDIA DGX Station Now Available") ## MSI XpertStation WS300 Based on NVIDIA DGX Station Now Available TAIPEI, Aug. 28, 2026 /PRNewswire/ — MSI announced that the XpertStation WS300… [](https://thailandbusinessnews.net/press-release/huawei-to-unveil-flagship-wearables-at-munich-chase-the-wild-campaign-event-on-sept-2/) ![Huawei to Unveil Flagship Wearables at Munich "Chase the Wild" Campaign Event on Sept. 2](https://i0.wp.com/mmx.prnasia.com/media/MS1974269/20260824043739EDT_image_1.jpg?resize=260%2C140&ssl=1 "Huawei to Unveil Flagship Wearables at Munich "Chase the Wild" Campaign Event on Sept. 2") ## Huawei to Unveil Flagship Wearables at Munich "Chase the Wild" Campaign Event on Sept. 2 MUNICH, Aug. 28, 2026 /PRNewswire/ — Huawei is gearing up for a… [](https://thailandbusinessnews.net/press-release/sk-hynix-holds-groundbreaking-ceremony-for-hbm-production-base-in-indiana-beginning-a-new-future-for-us-korea-ai/) ## SK hynix Holds Groundbreaking Ceremony for HBM Production Base in Indiana, "Beginning a New Future for US-Korea AI" Investing over $4 billion in Indiana fab and first ‘Made in USA’…