ERA Congress: Long-term data show sustained efficacy and safety of zigakibart in patients with IgA nephropathy - Thailand PR News - [Banking](https://thailandbusinessnews.net/category/banking/) - [Companies](https://thailandbusinessnews.net/category/companies/) - [Economy](https://thailandbusinessnews.net/category/economy/) - [Press Releases](https://thailandbusinessnews.net/category/press-release/) - [PR Newswire](https://thailandbusinessnews.net/pr-newswire-updates/) - [Tech](https://thailandbusinessnews.net/category/tech/) - [Tourism](https://thailandbusinessnews.net/category/tourism/) - [Press Release](https://thailandbusinessnews.net/category/press-release/) # ERA Congress: Long-term data show sustained efficacy and safety of zigakibart in patients with IgA nephropathy ##### Up next ![THE GENERATION ESSENTIALS GROUP AND BLACK SPADE ACQUISITION II CO COMPLETE BUSINESS COMBINATION](https://i0.wp.com/r2.thailandbusinessnews.net/2025/06/JUS_2715_edited.jpg?resize=200%2C110&ssl=1 "THE GENERATION ESSENTIALS GROUP AND BLACK SPADE ACQUISITION II CO COMPLETE BUSINESS COMBINATION") [](https://thailandbusinessnews.net/press-release/the-generation-essentials-group-and-black-spade-acquisition-ii-co-complete-business-combination/) ###### [THE GENERATION ESSENTIALS GROUP AND BLACK SPADE ACQUISITION II CO COMPLETE BUSINESS COMBINATION](https://thailandbusinessnews.net/press-release/the-generation-essentials-group-and-black-spade-acquisition-ii-co-complete-business-combination/) Published on 05 June 2025 ##### Author ##### [ CISION PRNewswire ](https://thailandbusinessnews.net/author/cision/) ##### Tags - [PRNewswire](https://thailandbusinessnews.net/tag/prnewswire/) VIENNA, June 5, 2025 /PRNewswire/ — New 100-week data from the ongoing Phase 1/2 study of zigakibart, an investigational anti-APRIL monoclonal antibody, reinforce its potential as a disease-modifying treatment for IgA nephropathy (IgAN). Findings presented today at the 62nd ERA Congress demonstrate sustained proteinuria remission, stable kidney function, and a reassuring safety profile. IgAN is the most common form of glomerular disease worldwide and a frequent cause of chronic kidney disease. Its pathogenesis is marked by inflammation and progressive kidney damage, which can lead to kidney failure. Many patients are unaware they have the condition until significant kidney damage has occurred, and 50% of IgAN patients will ultimately develop kidney failure. By targeting the APRIL pathway and reducing production of pathogenic galactose-debecause ofgA1), zigakibart addresses a key driver of disease progression. "Zigakibart is designed to intercept the initiating factor in IgAN pathogenesis, offering a new approach that may halt or significantly delay progression", explained lead investigator Professor Jonathan Barratt. The ADU-CL-19 trial included 40 adults with biopsy-confirmed IgAN and persistent proteinuria despite stable supportive therapy. Patients received zigakibart every two weeks via intravenous infusion or subcutaneous injection, in addition to maximally tolerated renin–angiotensin system inhibitors (RASi) unless RASi-intolerant – demonstrating efficacy beyond standard care. At Week 100, proteinuria was reduced by 60% from baseline. Over half of patients (55%) reached <500 mg/24 h, and 31% achieved <300 mg/24 h, indicating deeper remission. Estimated glomerular filtration rate (eGFR) remained stable across subgroups. "The consistency of eGFR stabilisation over 100 weeks, even across proteinuria response groups, is particularly encouraging," said Prof. Barratt. Treatment also led to sustained reductions in serum immunoglobulins, including a 74% drop in IgA and pathogenic Gd-IgA1, consistent with APRIL pathway inhibition. Zigakibart was well tolerated throughout. Most adverse events were mild or moderate, with no treatment-related serious infections or discontinuations. Infections were the most common AEs; the study coincided with a high prevalence of COVID-19. This is the longest duration of eGFR stabilisation reported for an anti-APRIL agent in IgAN. "These long-term results build confidence in zigakibart as a potential cornerstone therapy for IgAN," said Prof. Barratt. "We’re excited to see how the upcoming Phase 3 trials will further define its role." The global Phase 3 BEYOND study is now evaluating zigakibart in a broader population, with primary proteinuria endpoints at 40 weeks and long-term kidney function through 104 weeks. [Source link ](https://www.prnasia.com/story/archive/4700741_AE00741_0?rand=89749) ``` This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network ``` ##### You May Also Like [](https://thailandbusinessnews.net/press-release/from-one-online-classroom-to-400000-families-wukong-education-marks-its-9th-anniversary-with-a-growing-global-vision/) ![From One Online Classroom to 400,000 Families: WuKong Education Marks Its 9th Anniversary with a Growing Global Vision](https://i0.wp.com/r2.thailandbusinessnews.net/2025/10/1761298421_1.jpg?resize=260%2C140&ssl=1 "From One Online Classroom to 400,000 Families: WuKong Education Marks Its 9th Anniversary with a Growing Global Vision") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## From One Online Classroom to 400,000 Families: WuKong Education Marks Its 9th Anniversary with a Growing Global Vision MOUNTAIN VIEW, Calif., Oct. 24, 2025 /PRNewswire/ — WuKong turns nine! WuKong… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - October 24, 2025 [](https://thailandbusinessnews.net/press-release/buma-australia-secures-au740-million-multi-year-contract-extension-with-whitehaven-at-blackwater-mine-through-2030/) ![BUMA Australia Secures AU0 Million Multi-Year Contract Extension with Whitehaven at Blackwater Mine Through 2030](https://i0.wp.com/mma.prnasia.com/media2/2850125/Blackwater_Operation.jpg?resize=260%2C140&ssl=1 "BUMA Australia Secures AU0 Million Multi-Year Contract Extension with Whitehaven at Blackwater Mine Through 2030") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## BUMA Australia Secures AU$740 Million Multi-Year Contract Extension with Whitehaven at Blackwater Mine Through 2030 BUMA Australia Pty Ltd ("BUMA Australia"), a wholly owned subsidiary of PT… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - December 22, 2025 [](https://thailandbusinessnews.net/press-release/aima-brand-launches-in-sri-lanka-laying-out-important-node-along-the-belt-and-road-initiative/) ## AIMA Brand Launches in Sri Lanka, Laying Out Important Node Along the Belt and Road Initiative TIANJIN, China, Aug. 11, 2025 /PRNewswire/ — On June 30, 2025, AIMA Technology held… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - August 11, 2025 ##### Most Read - [![Priority Pass to accelerate travel innovation, backed by the Collinson Group's £500 million growth programme](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/priority-pass-to-accelerate-travel-innovation-backed-by-the-collinson-groups-500-million-growth-programme-2/ "Priority Pass to accelerate travel innovation, backed by the Collinson Group's £500 million growth programme") [Priority Pass to accelerate travel innovation, backed by the Collinson Group's £500 million growth programme](https://thailandbusinessnews.net/press-release/priority-pass-to-accelerate-travel-innovation-backed-by-the-collinson-groups-500-million-growth-programme-2/ "Priority Pass to accelerate travel innovation, backed by the Collinson Group's £500 million growth programme") - [![DORCO Tinkle Is Awarded with 2026 IDEA Finalist for Brand Renewal](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/dorco-tinkle-is-awarded-with-2026-idea-finalist-for-brand-renewal/ "DORCO Tinkle Is Awarded with 2026 IDEA Finalist for Brand Renewal") [DORCO Tinkle Is Awarded with 2026 IDEA Finalist for Brand Renewal](https://thailandbusinessnews.net/press-release/dorco-tinkle-is-awarded-with-2026-idea-finalist-for-brand-renewal/ "DORCO Tinkle Is Awarded with 2026 IDEA Finalist for Brand Renewal") - [![DORCO Wins 2026 Red Dot Award for Renewed Corporate Identity](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/dorco-wins-2026-red-dot-award-for-renewed-corporate-identity/ "DORCO Wins 2026 Red Dot Award for Renewed Corporate Identity") [DORCO Wins 2026 Red Dot Award for Renewed Corporate Identity](https://thailandbusinessnews.net/press-release/dorco-wins-2026-red-dot-award-for-renewed-corporate-identity/ "DORCO Wins 2026 Red Dot Award for Renewed Corporate Identity") - [![Dragonpass: AI Is Shifting the Membership Economy from Perks Redemption to Personalized Experiences](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/dragonpass-ai-is-shifting-the-membership-economy-from-perks-redemption-to-personalized-experiences/ "Dragonpass: AI Is Shifting the Membership Economy from Perks Redemption to Personalized Experiences") [Dragonpass: AI Is Shifting the Membership Economy from Perks Redemption to Personalized Experiences](https://thailandbusinessnews.net/press-release/dragonpass-ai-is-shifting-the-membership-economy-from-perks-redemption-to-personalized-experiences/ "Dragonpass: AI Is Shifting the Membership Economy from Perks Redemption to Personalized Experiences") - [![Modern Meadow and Bellroy Partner on Carry Products Made of Next-Generation Material](https://i0.wp.com/r2.thailandbusinessnews.net/2025/04/MODERN_MEADOW_LOGO_BLACK_PNG_Logo.jpg?fit=597%2C138&ssl=1&resize=40%2C40)](https://thailandbusinessnews.net/press-release/modern-meadow-and-bellroy-partner-on-carry-products-made-of-next-generation-material/ "Modern Meadow and Bellroy Partner on Carry Products Made of Next-Generation Material") [Modern Meadow and Bellroy Partner on Carry Products Made of Next-Generation Material](https://thailandbusinessnews.net/press-release/modern-meadow-and-bellroy-partner-on-carry-products-made-of-next-generation-material/ "Modern Meadow and Bellroy Partner on Carry Products Made of Next-Generation Material") - [![IMG Completes Acquisition of World Nomads, Expanding Global Travel Insurance Distribution](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/img-completes-acquisition-of-world-nomads-expanding-global-travel-insurance-distribution/ "IMG Completes Acquisition of World Nomads, Expanding Global Travel Insurance Distribution") [IMG Completes Acquisition of World Nomads, Expanding Global Travel Insurance Distribution](https://thailandbusinessnews.net/press-release/img-completes-acquisition-of-world-nomads-expanding-global-travel-insurance-distribution/ "IMG Completes Acquisition of World Nomads, Expanding Global Travel Insurance Distribution") ##### Subscribe via Email Enter your email address to subscribe and receive notifications of new posts by email. Email Address Subscribe [](https://thailandbusinessnews.net/press-release/huawei-launches-the-huawei-mate-90-series-equipped-with-the-flagship-tau-chipset-across-the-entire-series/) ![Huawei Launches the HUAWEI Mate 90 Series, Equipped with the Flagship Tau Chipset Across the Entire Series](https://i0.wp.com/mmx.prnasia.com/media/MS2000671/20261001053026EDT_image_1.jpg?resize=260%2C140&ssl=1 "Huawei Launches the HUAWEI Mate 90 Series, Equipped with the Flagship Tau Chipset Across the Entire Series") ## Huawei Launches the HUAWEI Mate 90 Series, Equipped with the Flagship Tau Chipset Across the Entire Series SHENZHEN, China, Oct. 1, 2026 /PRNewswire/ — Huawei today officially launched its… [](https://thailandbusinessnews.net/press-release/xpeng-to-launch-its-next-gen-ai-flagship-g9l-suv-and-showcase-its-physical-ai-lineup-at-the-2026-paris-motor-show/) ![XPENG to Launch Its Next-Gen AI Flagship G9L SUV and Showcase Its Physical AI Lineup at the 2026 Paris Motor Show](https://i0.wp.com/mmx.prnasia.com/media/MS2000669/Picture1.jpg?resize=260%2C140&ssl=1 "XPENG to Launch Its Next-Gen AI Flagship G9L SUV and Showcase Its Physical AI Lineup at the 2026 Paris Motor Show") ## XPENG to Launch Its Next-Gen AI Flagship G9L SUV and Showcase Its Physical AI Lineup at the 2026 Paris Motor Show XPENG will showcase its Physical AI ecosystem spanning its technology stack, humanoid… [](https://thailandbusinessnews.net/press-release/bahrain-to-convene-architects-of-the-future-economy-for-gateway-gulfs-fourth-edition-this-november/) ![Bahrain to Convene Architects of the Future Economy for Gateway Gulf's Fourth Edition This November](https://i0.wp.com/mmx.prnasia.com/media/MS2000662/Gateway-Gulf-2025.jpg?resize=260%2C140&ssl=1 "Bahrain to Convene Architects of the Future Economy for Gateway Gulf's Fourth Edition This November") ## Bahrain to Convene Architects of the Future Economy for Gateway Gulf's Fourth Edition This November At a pivotal moment for the global economy, international leaders will engage… [](https://thailandbusinessnews.net/press-release/incorp-singapore-rebrands-to-ascentium-singapore-connecting-clients-to-a-wider-ecosystem-for-growth/) ## InCorp Singapore Rebrands to Ascentium Singapore, Connecting Clients to a Wider Ecosystem for Growth Blending established local expertise with Ascentium’s global capabilities, the…