Earendil Labs Announces First Patient Dosed in a Phase IIa Trial of a Half-life Extended Anti-TL1A Antibody (HXN-1001) in Patients with Ulcerative Colitis - Thailand PR News - [Banking](https://thailandbusinessnews.net/category/banking/) - [Companies](https://thailandbusinessnews.net/category/companies/) - [Economy](https://thailandbusinessnews.net/category/economy/) - [Press Releases](https://thailandbusinessnews.net/category/press-release/) - [PR Newswire](https://thailandbusinessnews.net/pr-newswire-updates/) - [Tech](https://thailandbusinessnews.net/category/tech/) - [Tourism](https://thailandbusinessnews.net/category/tourism/) - [Press Release](https://thailandbusinessnews.net/category/press-release/) # Earendil Labs Announces First Patient Dosed in a Phase IIa Trial of a Half-life Extended Anti-TL1A Antibody (HXN-1001) in Patients with Ulcerative Colitis ##### Up next ![The Flamingo Estate Bathhouse by Kohler Debuts as a Nature‑Infused Wellness Sanctuary at Milan Design Week 2026](https://i0.wp.com/mma.prnasia.com/media2/2947459/Kohler.jpg?resize=200%2C110&ssl=1 "The Flamingo Estate Bathhouse by Kohler Debuts as a Nature‑Infused Wellness Sanctuary at Milan Design Week 2026") [](https://thailandbusinessnews.net/press-release/the-flamingo-estate-bathhouse-by-kohler-debuts-as-a-nature-infused-wellness-sanctuary-at-milan-design-week-2026/) ###### [The Flamingo Estate Bathhouse by Kohler Debuts as a Nature‑Infused Wellness Sanctuary at Milan Design Week 2026](https://thailandbusinessnews.net/press-release/the-flamingo-estate-bathhouse-by-kohler-debuts-as-a-nature-infused-wellness-sanctuary-at-milan-design-week-2026/) Published on 02 April 2026 ##### Author ##### [ CISION PRNewswire ](https://thailandbusinessnews.net/author/cision/) ##### Tags - [PRNewswire](https://thailandbusinessnews.net/tag/prnewswire/) WILMINGTON, Del., April 2, 2026 /PRNewswire/ — Earendil Labs, an AI-driven biotechnology company advancing next-generation biologics, today announced the first patient has been dosed in a Phase IIa clinical trial of HXN-1001, a half-life extended anti-TL1A antibody, in patients with ulcerative colitis, as well as enrollment completion in the Phase I trial of the antibody in healthy volunteers carried out in Australia. The Phase IIa trial is a randomized, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, and preliminary efficacy of HXN-1001 in ulcerative colitis patients. HXN-1001 is a half-life extended, next generation anti-TL1A antibody with great potential for the treatment of patients with inflammatory bowel disease (IBD) including ulcerative colitis and Crohn’s disease. In preclinical studies, HXN-1001 has demonstrated more potent efficacies in multiple in vitro assays and animal models than several benchmark products currently under clinical development. Besides the extended in vivo half-life, HXN-1001 is formulated at a high protein concentration for subcutaneous injection. Taken together, HXN-1001 represents a potentially more efficacious and more convenient treatment option for IBD patients. "In the Phase I study in healthy volunteers, HXN-1001 in single doses up to 1200 mg and multiple doses of 450 mg was well tolerated with a favorable safety profile. The antibody showed a half-life of about 8 weeks when dosed in the projected therapeutic dose range, with low incidence of anti-drug antibody response." Zhenping Zhu, MD, PhD, President & Co-CEO of Earendil Labs, commented, "We are working diligently to advance HXN-1001 clinical programs in a hope to bring a new and efficacious therapeutic option for IBD patients expeditiously." Jian Peng, PhD, CEO of Earendil Labs, stated, "The progression of HXN-1001 clinical development is a significant step on our pursuit of developing next-generation best-in-class biologic therapeutics in the treatment of patients suffering from IBD. We look forward to working closely with the clinical investigators and the IBD community to advance our development programs globally and to fully realize the great potential of HXN-1001." **About Earendil Labs** Earendil Labs is an AI-driven biotechnology company advancing next-generation biologics for patients with autoimmune diseases, cancer, and other areas of significant unmet medical need. By integrating artificial intelligence across the full R&D lifecycle, Earendil Labs and its affiliate Helixon Therapeutics have been building a scalable engine to systematically generate and advance high-quality therapeutic programs. The company’s AI-native approach enables efficient creation, optimization, and progression of protein-based biologics with the potential to be first-in-class and best-in-class, translating computational innovation into real clinical and patient impact. Through a combination of internal pipeline development and strategic partnerships, Earendil Labs aims to deliver transformative medicines to patients worldwide. [Source link ](http://www.prnasia.com/story/archive/4925830_CN25830_0?rand=89749) ``` This content was prepared by our news partner, Cision PR Newswire. The opinions and the content published on this page are the author’s own and do not necessarily reflect the views of Siam News Network ``` ##### You May Also Like [](https://thailandbusinessnews.net/press-release/shanghai-electric-deepens-cooperation-to-jointly-build-the-china-pakistan-economic-corridor-with-energy-and-talent-as-key-drivers/) ## Shanghai Electric Deepens Cooperation to Jointly Build the China-Pakistan Economic Corridor with Energy and Talent as Key Drivers Pakistani President Asif Ali Zardari Visits Shanghai Electric Headquarters Thar Flagship Project and Talent… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - September 22, 2025 [](https://thailandbusinessnews.net/press-release/ping-an-co-hosts-digital-finance-forum-at-world-internet-conference-asia-pacific-summit-driving-financial-digitalization-in-asia-pacific-with-ai/) ## Ping An Co-hosts Digital Finance Forum at World Internet Conference Asia-Pacific Summit Driving Financial Digitalization in Asia-Pacific with AI HONG KONG and SHANGHAI, April 16, 2025 /PRNewswire/ — On April 14 and… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - April 16, 2025 [](https://thailandbusinessnews.net/press-release/smart-automation-meets-medical-innovation-icp-das-icp-das-bmp-at-manufacturing-world-tokyo-2025/) ![Smart Automation Meets Medical Innovation: ICP DAS & ICP DAS-BMP at Manufacturing World Tokyo 2025](https://i0.wp.com/r2.thailandbusinessnews.net/2025/06/ICP_DAS___Logo_Logo.jpg?resize=260%2C140&ssl=1 "Smart Automation Meets Medical Innovation: ICP DAS & ICP DAS-BMP at Manufacturing World Tokyo 2025") - [Press Release](https://thailandbusinessnews.net/category/press-release/) ## Smart Automation Meets Medical Innovation: ICP DAS & ICP DAS-BMP at Manufacturing World Tokyo 2025 HSINCHU, June 24, 2025 /PRNewswire/ — ICP DAS and its biomedical business… - [CISION PRNewswire](https://thailandbusinessnews.net/author/cision/ "View all posts by CISION PRNewswire") - June 24, 2025 ##### Most Read - [![NYSE Honors Victims of 9/11: NYSE Content Update](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/nyse-honors-victims-of-9-11-nyse-content-update/ "NYSE Honors Victims of 9/11: NYSE Content Update") [NYSE Honors Victims of 9/11: NYSE Content Update](https://thailandbusinessnews.net/press-release/nyse-honors-victims-of-9-11-nyse-content-update/ "NYSE Honors Victims of 9/11: NYSE Content Update") - [![Vitafoods Asia Announces Strategic Move to Kuala Lumpur for 2027 Edition](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/vitafoods-asia-announces-strategic-move-to-kuala-lumpur-for-2027-edition/ "Vitafoods Asia Announces Strategic Move to Kuala Lumpur for 2027 Edition") [Vitafoods Asia Announces Strategic Move to Kuala Lumpur for 2027 Edition](https://thailandbusinessnews.net/press-release/vitafoods-asia-announces-strategic-move-to-kuala-lumpur-for-2027-edition/ "Vitafoods Asia Announces Strategic Move to Kuala Lumpur for 2027 Edition") - [![Ivonescimab Versus Pembrolizumab in First-Line PD-L1-Positive NSCLC: Positive Overall Survival Results from HARMONi-2 Presented at WCLC 2026](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/ivonescimab-versus-pembrolizumab-in-first-line-pd-l1-positive-nsclc-positive-overall-survival-results-from-harmoni-2-presented-at-wclc-2026/ "Ivonescimab Versus Pembrolizumab in First-Line PD-L1-Positive NSCLC: Positive Overall Survival Results from HARMONi-2 Presented at WCLC 2026") [Ivonescimab Versus Pembrolizumab in First-Line PD-L1-Positive NSCLC: Positive Overall Survival Results from HARMONi-2 Presented at WCLC 2026](https://thailandbusinessnews.net/press-release/ivonescimab-versus-pembrolizumab-in-first-line-pd-l1-positive-nsclc-positive-overall-survival-results-from-harmoni-2-presented-at-wclc-2026/ "Ivonescimab Versus Pembrolizumab in First-Line PD-L1-Positive NSCLC: Positive Overall Survival Results from HARMONi-2 Presented at WCLC 2026") - [![LOTTE HOTELS & RESORTS Launches Exclusive Travel Pass Featuring Limited-Edition Korean Heritage Transit Cards](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/lotte-hotels-resorts-launches-exclusive-travel-pass-featuring-limited-edition-korean-heritage-transit-cards/ "LOTTE HOTELS & RESORTS Launches Exclusive Travel Pass Featuring Limited-Edition Korean Heritage Transit Cards") [LOTTE HOTELS & RESORTS Launches Exclusive Travel Pass Featuring Limited-Edition Korean Heritage Transit Cards](https://thailandbusinessnews.net/press-release/lotte-hotels-resorts-launches-exclusive-travel-pass-featuring-limited-edition-korean-heritage-transit-cards/ "LOTTE HOTELS & RESORTS Launches Exclusive Travel Pass Featuring Limited-Edition Korean Heritage Transit Cards") - [![Picarro Launches the P-Cubed Mobile App, Putting Smarter Natural Gas Leak Investigations in Field Technicians' Hands](https://i0.wp.com/r2.thailandbusinessnews.net/2025/10/Picarro_launches_PCubed_Mobile_App.jpg?fit=600%2C336&ssl=1&resize=40%2C40)](https://thailandbusinessnews.net/press-release/picarro-launches-the-p-cubed-mobile-app-putting-smarter-natural-gas-leak-investigations-in-field-technicians-hands/ "Picarro Launches the P-Cubed Mobile App, Putting Smarter Natural Gas Leak Investigations in Field Technicians' Hands") [Picarro Launches the P-Cubed Mobile App, Putting Smarter Natural Gas Leak Investigations in Field Technicians' Hands](https://thailandbusinessnews.net/press-release/picarro-launches-the-p-cubed-mobile-app-putting-smarter-natural-gas-leak-investigations-in-field-technicians-hands/ "Picarro Launches the P-Cubed Mobile App, Putting Smarter Natural Gas Leak Investigations in Field Technicians' Hands") - [![CGTN: How the SCO opens up opportunities for regional development as it turns 25](https://secure.gravatar.com/avatar/96e712b5408b51145de772098c3ff3417ce8a11555b7c388d84204c5769f5631?s=40&d=blank&r=g)](https://thailandbusinessnews.net/press-release/cgtn-how-the-sco-opens-up-opportunities-for-regional-development-as-it-turns-25/ "CGTN: How the SCO opens up opportunities for regional development as it turns 25") [CGTN: How the SCO opens up opportunities for regional development as it turns 25](https://thailandbusinessnews.net/press-release/cgtn-how-the-sco-opens-up-opportunities-for-regional-development-as-it-turns-25/ "CGTN: How the SCO opens up opportunities for regional development as it turns 25") ##### Subscribe via Email Enter your email address to subscribe and receive notifications of new posts by email. Email Address Subscribe [](https://thailandbusinessnews.net/press-release/rejuran-cosmetics-brings-k-beauty-to-lafc-korean-heritage-night-as-proud-skincare-partner/) ![REJURAN® COSMETICS Brings K-Beauty to LAFC Korean Heritage Night as Proud Skincare Partner](https://i0.wp.com/mmx.prnasia.com/media/MS1987240/20260914024604EDT_image_1.jpg?resize=260%2C140&ssl=1 "REJURAN® COSMETICS Brings K-Beauty to LAFC Korean Heritage Night as Proud Skincare Partner") ## REJURAN® COSMETICS Brings K-Beauty to LAFC Korean Heritage Night as Proud Skincare Partner Korea’s original PDRN brand connected with Los Angeles football fans through… [](https://thailandbusinessnews.net/press-release/miral-invests-aed-12-billion-to-shape-the-next-phase-of-yas-islands-growth-2/) ![Miral Invests AED 12 billion to Shape the Next Phase of Yas Island's Growth](https://i0.wp.com/mmx.prnasia.com/media/MS1986572/Yas-Island-Abu-Dhabi-3.jpg?resize=260%2C140&ssl=1 "Miral Invests AED 12 billion to Shape the Next Phase of Yas Island's Growth") ## Miral Invests AED 12 billion to Shape the Next Phase of Yas Island's Growth A robust five-year pipeline of new developments and enhancements will expand… [](https://thailandbusinessnews.net/press-release/miral-invests-aed-12-billion-to-shape-the-next-phase-of-yas-islands-growth/) ![Miral Invests AED 12 billion to Shape the Next Phase of Yas Island's Growth](https://i0.wp.com/mmx.prnasia.com/media/MS1986572/Yas-Island-Abu-Dhabi-3.jpg?resize=260%2C140&ssl=1 "Miral Invests AED 12 billion to Shape the Next Phase of Yas Island's Growth") ## Miral Invests AED 12 billion to Shape the Next Phase of Yas Island's Growth A robust five-year pipeline of new developments and enhancements will expand… [](https://thailandbusinessnews.net/press-release/wuhan-is-really-something/) ## Wuhan is really something WUHAN, China, Sept. 14, 2026 /PRNewswire/ — On Sept. 14, the bilingual…